Neurofilament light chain: A novel blood biomarker in patients with ataxia telangiectasia
نویسندگان
چکیده
AimNeurofilament light chain (NfL) is recognized as a blood biomarker in several neurodegenerative disorders, but its possible relevance Ataxia Telangiectasia (A-T) has not been examined. The aim of this study was to investigate the potential NfL concentrations patients with A-T.MethodBlood (serum/plasma) were measured Dutch and an American cohort A-T compared control values. Additionally, correlations between disease phenotype (classic versus variant A-T) studied.ResultsIn total 40 (23 17 American) (32 classic 7 age- gender-matched (to cohort) healthy controls included study. Blood age ? 12 years elevated matched controls. Patients > also had higher (here: age-dependent reference values found literature). than phenotype.ConclusionBlood are appear correlate variant). Therefore, may be promising A-T.
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ژورنال
عنوان ژورنال: European Journal of Paediatric Neurology
سال: 2021
ISSN: ['1532-2130', '1090-3798']
DOI: https://doi.org/10.1016/j.ejpn.2021.04.002